Pharmacological Actions and Clinical Uses

Thrombolytic drugs are indicated for the management of severe pulmonary embolism, deep vein thrombosis, and arterial thromboembolism and are especially important therapy after myocardial infarction and acute ischemic stroke. Thrombolysis must be accomplished quickly after myocardial or cerebral infarction, since clots become more difficult to lyse as they age. Recanalization after approximately 6 hours provides diminishing benefit to the infarcted area. The incidence of rethrombosis and rein-farction is greater when thrombolytic drugs with shorter plasma half-lives are used. Concurrent administration with heparin followed by warfarin, as well as antiplatelet drugs, is advocated to reduce reocclusion. Adjunctive anticoagulant and antiplatelet drugs may contribute to bleeding during thrombolytic therapy.

Your Heart and Nutrition

Your Heart and Nutrition

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