Pharmacokinetics

Many psychomotor stimulants possess activities similar to those of amphetamine and have been discussed previously (see Chapter 10). Of primary importance to our discussion of the psychomotor stimulants are amphetamine (Adderall, Benzedrine, Dexedrine), methampheta-mine (Desoxyn), and methylphenidate (Concerta, Ritalin, Metadate, Methylin).

All of these compounds are well absorbed after oral administration, leaving injectable forms with few legitimate applications. Although several catabolic pathways metabolize the amphetamines, a considerable portion of untransformed drug is excreted in the urine. Thus, it is possible to ion-trap this weak organic base by acidifying the urine, thereby reducing its reabsorption in the renal tubules and enhancing its clearance.

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