Pharmacokinetics

The pharmacokinetic characteristics of dofetilide are summarized below. Although the absorption of dofetilide is delayed by ingestion of food, the total bioavailability is not affected. Dosing requires adjustment in patients with renal insufficiency.

Oral bioavailability >90%

Onset of action 0.5 hour

Peak response Duration of action Plasma half-life Primary route of metabolism Primary route of excretion

Therapeutic serum concentration

23 hours 8-10 hours 7-10 hours Hepatic (CYP3A4)

Renal (80% unchanged;

20% metabolites) Not established

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