Pharmacokinetics

The pharmacokinetic characteristics of dofetilide are summarized below. Although the absorption of dofetilide is delayed by ingestion of food, the total bioavailability is not affected. Dosing requires adjustment in patients with renal insufficiency.

Oral bioavailability >90%

Onset of action 0.5 hour

Peak response Duration of action Plasma half-life Primary route of metabolism Primary route of excretion

Therapeutic serum concentration

23 hours 8-10 hours 7-10 hours Hepatic (CYP3A4)

Renal (80% unchanged;

20% metabolites) Not established

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment