Pharmacokinetics

The pharmacokinetic characteristics of acebutolol:

Oral bioavailability 70%

Onset of action 1-3 hours

Peak response Duration of action Plasma half-life Primary route of metabolism Primary route of excretion

Therapeutic serum concentration

3-8 hours 12-24 hours 3-4 hours Hepatic

fecal (50-60%) Not established

Clinical Uses

Acebutolol is effective in the management of the patient with essential hypertension, angina pectoris, and ventricular arrhythmias. Antiarrhythmic effects are observed with the patient both at rest and taking exercise.

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