A comparison of the pharmacokinetic properties of these agents is listed in Table 19.2. All three drugs are well absorbed following oral administration. Verapamil and diltiazem undergo greater first-pass metabolism relative to nifedipine, resulting in lower bioavailability of the former two drugs. Hepatic metabolism of nifedipine is complete, yielding inactive metabolites; this is unlike verapamil and diltiazem, whose metabolites have pharmacological activity. Verapamil is metabolized stereose-lectively in favor of the more active (-) enantiomer, thus requiring higher plasma concentrations after oral administration.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment