Pharmacokinetics

The pharmacokinetic characteristics of tocainide:

Oral bioavailability Onset of action Peak response Duration of action Plasma half-life

Approximately 100% Not known 0.5-2 hours 8 hours 15 hours

Primary route of metabolism Primary route of excretion Therapeutic serum

Clinical Uses

Hepatic

Renal (40% unchanged) 3-11 ^g /mL concentration

Tocainide is indicated for the treatment of symptomatic ventricular arrhythmias refractory to more conventional therapy. Serious noncardiac adverse effects limit its use to patients with life-threatening arrhythmias.

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