The pharmacokinetic characteristics of tocainide:
Oral bioavailability Onset of action Peak response Duration of action Plasma half-life
Approximately 100% Not known 0.5-2 hours 8 hours 15 hours
Primary route of metabolism Primary route of excretion Therapeutic serum
Renal (40% unchanged) 3-11 ^g /mL concentration
Tocainide is indicated for the treatment of symptomatic ventricular arrhythmias refractory to more conventional therapy. Serious noncardiac adverse effects limit its use to patients with life-threatening arrhythmias.
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