Pharmacokinetics

The pharmacokinetic characteristics of lidocaine:

Oral bioavailability Onset of action

Peak response Duration of action

Plasma half-life Primary route of metabolism Primary route of excretion Therapeutic serum concentration

5-15 minutes intramuscularly (IM); immediate intravenously (IV) Unknown

60-90 minutes IM; 10-20

minutes IV 1-2 hours 90% hepatic

10% renal (unchanged), remainder as metabolites 1.5-5.0 ^g/mL

Lidocaine may produce clinically significant hypotension, but this is exceedingly uncommon if the drug is given in moderate dosage. Depression of an already damaged myocardium may result from large doses.

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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