The pharmacokinetic characteristics of lidocaine:

Oral bioavailability Onset of action

Peak response Duration of action

Plasma half-life Primary route of metabolism Primary route of excretion Therapeutic serum concentration

5-15 minutes intramuscularly (IM); immediate intravenously (IV) Unknown

60-90 minutes IM; 10-20

minutes IV 1-2 hours 90% hepatic

10% renal (unchanged), remainder as metabolites 1.5-5.0 ^g/mL

Lidocaine may produce clinically significant hypotension, but this is exceedingly uncommon if the drug is given in moderate dosage. Depression of an already damaged myocardium may result from large doses.

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