Pharmacokinetic Properties

Both triamterene and amiloride are effective after oral administration. Diuresis ensues within 2 to 4 hours after administration, although a maximum therapeutic effect may not be seen for several days. Both drugs cause a modest (2-3%) increase in Na+ and HCO3ex-cretion, a reduction in K+ and H+ loss, and a variable effect on Cl" elimination. Approximately 80% of an administered dose of triamterene is excreted in the urine as metabolites; amiloride is excreted unchanged.

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