Pagets Disease

Paget's disease is an uncommon disorder of bone characterized by mixed lytic and sclerotic bone changes.

These individuals have areas of increased bone resorption and other areas of abnormal new bone formation. The abnormal bone formation can result in pain, deformity, and fracture of affected bones. The bisphospho-nates and calcitonin are most commonly used in the treatment of this disease. Long-term continuous use of bisphosphonates can be associated with the induction of osteomalacia through a direct impairment of new bone formation. Therefore, the bisphosphonates are given in a cyclic pattern to treat Paget's disease.

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