Other Imidazoles

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A number of topical imidazoles are available for the treatment of cutaneous and mucous membrane candidi-asis, ringworm, and tinea versicolor. Butoconazole (Femstat) is an effective topical agent for vaginal can-didiasis; terconazole (Terazol) is effective in the treatment of vaginal candidiasis; and econazole (Spectazole) is useful in the treatment of superficial fungal infections of the skin, achieving high tissue levels in the stratum corneum. Oxiconazole nitrate (Oxistat) and sulconazole nitrate (Exelderm) are topical imidazole derivatives available for the treatment of dermatophyte infections and pityriasis (tinea versicolor). Tioconazole (Vagistat) is available without a prescription for the treatment of dermatophyte infections and candidiasis.

All of these agents have minimal systemic absorption when applied topically, but occasionally use of these drugs can result in systemic toxicity.

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