Opioid Antagonists

Naloxone and naltrexone are pure opioid antagonists synthesized by relatively minor changes in the morphine structure. Alteration of the substituent on the piperidine nitrogen from a methyl group to a longer side chain changes the drug from an agonist to an antagonist.

Opioid antagonists bind to the opioid receptor with high affinity and have low efficacy. The pure antagonists block the effects of opioids at all opioid receptors. However, as previously discussed, the dose required for naloxone blockade of the ^-receptor versus the k-opioid receptor is several times as much. All opioid antagonists will precipitate withdrawal in opioid-depend-ent patients.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment