Opioid Antagonists

Naloxone and naltrexone are pure opioid antagonists synthesized by relatively minor changes in the morphine structure. Alteration of the substituent on the piperidine nitrogen from a methyl group to a longer side chain changes the drug from an agonist to an antagonist.

Opioid antagonists bind to the opioid receptor with high affinity and have low efficacy. The pure antagonists block the effects of opioids at all opioid receptors. However, as previously discussed, the dose required for naloxone blockade of the ^-receptor versus the k-opioid receptor is several times as much. All opioid antagonists will precipitate withdrawal in opioid-depend-ent patients.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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