Triamterene (Dyrenium) or amiloride (Midamor) administration results in changes in urinary electrolyte patterns that are qualitatively similar to those produced by spironolactone. The mechanism by which these agents bring about the alterations in electrolyte loss, however, is quite different. Triamterene and amiloride produce their effects whether or not aldosterone or any other mineralocorticoid is present. The action of these two drugs is clearly unrelated to endogenous mineralo-corticoid activity, and these drugs are effective in adrena-lectomized patients.
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