Postsynaptic Hj- and H2-receptors are responsible for a variety of processes in the CNS. Hj-receptors mediate the maintenance of wakeful states, while Hj- and H2-receptors participate in the regulation of blood pres-sure,body temperature, fluid homeostasis, and pain sensation. Presynaptic H3-receptors serve as feedback inhibitors of the release of histamine, norepinephrine, and other neurotransmitters.
In the periphery, Hj-receptors on sensory neurons in the epidermis and dermis mediate itch and pain, respectively. Autonomic afferent nerve endings may be similarly stimulated by histamine. As in the CNS, presynap-tic H3-receptors act in a feedback inhibitory capacity.
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