Oxaprozin (Daypro) has pharmacological properties that are similar to those of other propionic acid derivatives. However, it has a very long half-life (more than 40 hours) and therefore can be effective with once-a-day treatment.
Nabumetone (Relafen) has antiinflammatory, antipyretic, and analgesic properties. It is converted by liver enzymes to an active metabolite that is a potent COX inhibitor. Although nabumetone shares many of the adverse effects of other NSAIDs, it appears to produce a lower incidence of GI ulceration.
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