Mirtazapine (Remeron) enhances both serotonergic and noradrenergic neurotransmission. By blocking presynaptic a2-adrenoceptors, mirtazapine causes release of norepinephrine. Indirectly, through noradrener-gic modulation of serotonin systems, mirtazapine also causes increased release of serotonin. It is an antagonist

TABLE 33.2 Common Side Effects of Therapeutic Doses of Antidepressants





Weight Gain

Sexual Dysfunction



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