Mirtazapine

Mirtazapine (Remeron) enhances both serotonergic and noradrenergic neurotransmission. By blocking presynaptic a2-adrenoceptors, mirtazapine causes release of norepinephrine. Indirectly, through noradrener-gic modulation of serotonin systems, mirtazapine also causes increased release of serotonin. It is an antagonist

TABLE 33.2 Common Side Effects of Therapeutic Doses of Antidepressants

Agent

Sedation

Anticholinergic

Orthostasis

Weight Gain

Sexual Dysfunction

SSRIs

+/-

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