Mechanism of Ganglionic Stimulation

Nicotine, lobeline, trimethylammonium, and DMPP stimulate all autonomic ganglia by simple combination with ganglionic nicotinic receptors on the postsynaptic membrane. This leads to membrane depolarization, an influx of sodium and calcium ions, and the generation of a fast EPSP. These agents produce general stimulation of autonomic ganglia and a complex pattern of mixed sympathetic and parasympathetic responses.

In addition to autonomic ganglia, nicotinic receptors are found in a variety of organs, and their stimulation will produce quite different results in these different tissues. Activation of nicotinic receptors on the plasma membrane of the cells of the adrenal medulla leads to the exo-cytotic release of epinephrine and norepinephrine; stimulation of nicotinic receptors at the neuromuscular junction results in the contraction of skeletal muscle (see

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Responses

  • Ferdinanda
    How ganglionic stimulation work?
    2 years ago

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