Mechanism of Action

Cyclosporine can bind to the cytosolic protein cy-tophilin C. This drug-protein complex inhibits cal-cineurin phosphatase activity, which leads to a decreased synthesis and release of several cytokines, including interleukins IL-2, IL-3, IL-4, interferon-a, and tumor necrosis factor.

Cyclosporine exhibits a high degree of specificity in its actions on T cells without significantly impairing B-cell activity. It can inhibit the T cell-dependent limb of antibody production by lymphocytes by preventing the differentiation of B cells into antibody-secreting plasma cells. Because T cells appear to require IL-2 stimulation for their continuous growth, cyclosporine impairs the proliferative response of T cells to antigens. However, once T cells have been stimulated by antigens to synthesize IL-2, cyclosporine cannot suppress the proliferation of T cells induced by this cytokine.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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