Mechanism of Action

Chloramphenicol (Chloromycetin) is a nitrobenzene derivative that affects protein synthesis by binding to the 50S ribosomal subunit and preventing peptide bond formation. It prevents the attachment of the amino acid end of aminoacyl-tRNA to the A site, hence the association of peptidyltransferase with the amino acid substrate. Resistance due to changes in the ribosome-binding site results in a decreased affinity for the drug, decreased permeability, and plasmids that code for enzymes that degrade the antibiotic.

The drug-induced inhibition of mitochondrial protein synthesis is probably responsible for the associated toxicity.

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

Get My Free Ebook

Post a comment