A cannabinoid receptor identified in the brain of several species, including humans, is termed CB1. It is one of the most abundant receptors in the CNS, and its distribution within the brain reflects the pharmacological effects produced by A9-THC. High receptor densities in the extrapyramidal motor system and the cerebellum are consistent with the actions of cannabinoids on many forms of movement. The effects of cannabinoids on cognition and memory may be due to the relatively dense receptor populations in the hippocampus and cortex. The presence of cannabinoid receptors in the ventro-medial striatum and nucleus accumbens suggests an association with dopamine neurons hypothesized to mediate brain reward.
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