Mechanism of Action

Thrombolytic drugs are plasminogen activators. The ideal thrombolytic agent is one that can be administered intravenously to produce clot-selective fibrinolysis without activating plasminogen to plasmin in plasma. Older (first generation) thrombolytic agents are not clot selective, and appreciable systemic fibrinogenolysis accompanies successful clot lysis. Newer (second generation) thrombolytic agents bind to fibrin and activate fibrinoly-sis more than fibrinogenolysis. Third-generation agents have improved fibrin specificity and pharmacokinetic properties.

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