Mechanism of Action

Unlike heparin, the oral anticoagulants induce hypoco-agulability only in vivo. They are vitamin K antagonists. Vitamin K is required to catalyze the conversion of the precursors of vitamin K-dependent clotting factors II, VII, IX, and X. This involves the posttranslational 7-car-boxylation of glutamic acid residues at the N-terminal end of the proteins. The 7-carboxylation step is linked to a cycle of enzyme reactions involving the active hy-droquinone form of vitamin K (K1H2).The regeneration of K1H1 by an epoxide reductase is blocked by the oral anticoagulants. These drugs thus cause hypocoagulabil-ity by inducing the formation of structurally incomplete clotting factors.

Commercial warfarin is a racemic mixture of S- and R-enantiomers; S-warfarin is more potent than R-war-farin.

Dealing With Erectile Dysfunction

Dealing With Erectile Dysfunction

Whether you call it erectile dysfunction, ED, impotence, or any number of slang terms, erection problems are something many men have to face during the course of their lifetimes.

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