Lipid Formulations of Amphotericin B

Three lipid formulations of amphotericin B (ampho-tericin B colloidal dispersion: Amphocil, Amphotec; amphotericin B lipid complex: Ablecet; and liposomal amphotericin B: Ambisome) have been developed in an attempt to reduce the toxicity profile of this drug and to increase efficacy. Formulating amphotericin with lipids alters drug distribution, with lower levels of drug in the kidneys, reducing the incidence of nephrotoxicity. The lipid formulations appear to be equivalent to conventional amphotericin B both in the treatment of documented fungal infections and in the empirical treatment of the febrile neutropenic patient. While less toxic, the lipid formulations are significantly more expensive than conventional amphotericin B.

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