Lipid Formulations of Amphotericin B

Three lipid formulations of amphotericin B (ampho-tericin B colloidal dispersion: Amphocil, Amphotec; amphotericin B lipid complex: Ablecet; and liposomal amphotericin B: Ambisome) have been developed in an attempt to reduce the toxicity profile of this drug and to increase efficacy. Formulating amphotericin with lipids alters drug distribution, with lower levels of drug in the kidneys, reducing the incidence of nephrotoxicity. The lipid formulations appear to be equivalent to conventional amphotericin B both in the treatment of documented fungal infections and in the empirical treatment of the febrile neutropenic patient. While less toxic, the lipid formulations are significantly more expensive than conventional amphotericin B.

Was this article helpful?

0 0
How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book


Post a comment