Lactamase Inhibitor Combinations

Several formulations combine a p-lactam antibiotic with a p-lactamase inhibitor (ampicillin-sulbactam [Unasyn], ticarcillin-clavulanic acid [Timentin], piper-acillin-tazobactam [Zosyn], and amoxicillin-clavulanic acid [Augmentin]). All of the p-lactamase inhibitor combinations except amoxicillin-clavulanic acid are parenteral formulations. Amoxicillin-clavulanic acid is the only combination drug with oral bioavailability. Elimination of the combination drugs occurs primarily by renal excretion. Therefore, all of the p-lactamase inhibitor combinations require dose adjustments in patients with renal insufficiency. The addition of the p-lactamase inhibitor significantly broadens the spectrum of antibacterial activity against p-lactamase-producing organisms. Consequently, these drugs have clinical use in treating infections with known or suspected mixed bacterial flora, such as biliary infections, diabetic foot ulcers, endomyometritis, and peritonitis.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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