TABLE 9.2 Drugs that interfere with Specific Steps in Chemical Transmission
Synthesis of transmitter
Storage of transmitter
Release of transmitter
Combination of transmitter with receptor
Destruction or removal of transmitter from site of action
Recovery of postsynaptic cell from the effects of the transmitter a-Methyldopa Reserpine Guanethidine Prazosin (a-receptors) Propranolol (ß-receptors) Tolcapone (COMT inhibitor) Phenelzine (MAO inhibitor) Tricyclic antidepressants (inhibit neuronal transport) None known
Atropine (muscarinic receptors)
d-Tubocurarine (nicotinic receptors)
Physostigmine (cholinesterase inhibitor)
COMT, catechol-0-methyltransferase;MAO, monoamine oxidase.
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