L

TABLE 9.2 Drugs that interfere with Specific Steps in Chemical Transmission

Transmission Step

Adrenergic Nerves

Cholinergic Nerves

Synthesis of transmitter

Storage of transmitter

Release of transmitter

Combination of transmitter with receptor

Destruction or removal of transmitter from site of action

Recovery of postsynaptic cell from the effects of the transmitter a-Methyldopa Reserpine Guanethidine Prazosin (a-receptors) Propranolol (ß-receptors) Tolcapone (COMT inhibitor) Phenelzine (MAO inhibitor) Tricyclic antidepressants (inhibit neuronal transport) None known

Hemicholinium

None known

Botulinum toxin

Atropine (muscarinic receptors)

d-Tubocurarine (nicotinic receptors)

Physostigmine (cholinesterase inhibitor)

Succinylcholine

COMT, catechol-0-methyltransferase;MAO, monoamine oxidase.

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