TABLE 32.2 Categorization of Anticonvulsants by Their Proposed Mechanism
Class Description Drugs
Type IV Noncategorized
Block SRF by enhancing sodium channel inactivation
Multiple actions: enhance GABAergic inhibition, reduce T-calcium currents, and possibly block SRF
Block T-calcium currents only Only enhances GABAergic inhibition
Has no known effect on SRF, GABAergic inhibition, or T-calcium currents
Adapted with permission from designation of classes described by Macdonald RL and Meldrum BS. In Levy RH et al. (eds.). Antiepileptic
"Felbamate probably possesses other actions.
4The mechanisms of action of gabapentin are unknown.
SRF, sustained high-frequency repetitive firing.
vance, since compounds in a particular category are often used for the same clinical indication. For a proposed mechanism of action to be considered relevant for a given drug, the effect must occur at concentrations similar to those that are likely to be achieved therapeuti-cally.
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