TABLE 36.1 Biological Effects of Eicosanoids

Eicosanoid Primary Biological Effects



LTC4, D4, E4 LTB4

Vasodilation, decreased gastric acid secretion, bronchodilation Vasodilation, decreased gastric acid secretion, pain sensitization, uterine contraction, cervical ripening, maintenance of patent ductus arteriosus, bronchodilation, fever Bronchoconstriction, uterine contraction, increases drainage from aqueous humor Vasodilation, maintenance of patent ductus arteriosus, inhibition of platelet aggregation, pain sensitization, gastric cytoprotec-tion

Platelet aggregation, bronchoconstriction Bronchoconstriction

Chemoattraction and activation of polymorphonuclear leukocytes uterus following fetal death, missed abortion, or benign hydatidiform mole. Carboprost (Hemabate) is a PGF2 analogue that can be used to terminate pregnancy or to control refractory postpartum bleeding by stimulating uterine contraction. Primary pulmonary hypertension can be treated by the synthetic PGI epoprostenol (Flolan). Elevated intraocular pressure may be treated with latanoprost (Xalatan), an analogue of PGF2. Zafirlukast (Accolate) is an oral leukotriene receptor antagonist for control of the inflammatory process of asthma (see Chapter 39). Zileuton (Zyflo) inhibits the first enzyme in the lipoxygenase pathway and is used for the treatment of asthma.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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