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A 36-year-old steroid-dependent man, an asthmatic and injection drug user, presents with a cough, 10-lb weight loss, and general weakness. His recent HIV screening was negative. He is taking oral prednisone 20 mg per day and denies any drug allergies. Upon examination, he appears to be chronically ill with a low-grade temperature of 100°F (38°C). His physical examination produced benign findings except for bilateral rhonchi over the apical lung fields. A presumptive diagnosis of pulmonary tuberculosis is based on the history and the appearance of right apical infiltrates on the chest radiograph. Four-drug therapy with isoniazid, ri-fampin, pyrazinamide, and ethambutol was ordered along with pyridoxine supplements pending the final culture and susceptibilities.

Metabolism of which ONE of the above-mentioned drugs is genetically predetermined?

(A) Rifampin

(C) Pyrazinamide

(D) Ethambutol

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