A. D. has refused to go for a yearly physical examination for more than 15 years despite a family history of cardiovascular disease. Over the past 6 months, A. D. has had to cut down and then eliminate his weekly soccer games because of extreme shortness of breath. Exasperated over his inability to exercise, A. D. goes to a primary care physician and is diagnosed with moderate to severe hypertension with a markedly enlarged heart. Unfortunately, A. D. has significant liver impairment from a previous bout of hepatitis. Based on knowledge of the renin-angiotensin system and the specifics concerning drugs targeted against this system, provide a rationale for use of two drugs to treat the cardiovascular disease in this patient.

Answer: This patient has congestive heart failure from long-standing hypertension. In addition, the patient has compromised liver function, limiting the choice of drug. Drugs that inhibit the renin-angiotensin system, specifically ACE inhibitors, are

Atrial natriuretic peptide is synthesized by cleavage of a larger precursor polypeptide.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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