Iv

Quinidine

Procainamide

Disopyramide

Moricizine"

Lidocaine

Phenytoin

Tocainide

Moricizine"

Mexiletine

Flecainide

Propafenone

Propranolol

Metoprolol

Nadolol

Acebutolol

Atenolol

Pindolol

Timolol

Sotalol

Esmolol4

Amiodarone

Bretylium

Sotalol

Ibutilide

Dofetilide

Verapamil

Diltiazem

BepridiP

Decrease Vmax of phase 0, increase refractory period, moderately decrease conduction velocity, decrease fast inward sodium current, inhibit potassium repolarization current.

Minimally change Vmax of phase 0, decrease cardiac action potential duration, decrease inward sodium current in ventricular muscle, increase outward potassium current.

Markedly decrease Vmax of phase 0, profoundly decrease ventricular conduction velocity, markedly inhibit inward sodium current. High potential for proarrhythmia.

P-Adrenoceptor antagonist, cardiac membrane stabilization, indirect effect on sinoatrial node to decrease rate of spontaneous diastolic depolarization. Indirect effect on A-V node to decrease conduction velocity and prolong ERP.

Prolong ventricular action potential, prolong refractoriness, inhibit potassium repolarization currents. Prolong QTc interval. Potential for proarrhythmia (torsades de pointes tachyarrhythmia).

Inhibit the slow inward calcium current, minimal effect (decrease) on ventricular action potential, major effects on the atrioventricular node to slow conduction velocity and increase the ERP.

"Mixed class IA/IB drug.

'Ultra-short-acting p-adrenoceptor blocking agent. cMay also show class III activity.

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