Minocin, Vectrin venereum, and psittacosis), and nonspecific urethritis. They are also effective in the treatment of brucellosis, tularemia, and infections caused by Pasteurella and Mycoplasma spp., although other agents may be equally effective. Tetracyclines are clinically effective in acne because of their antioxidant effect on the degranulated neutrophils in the comedone acidic contents (in which long-term low-dose therapy is popular). Mild to moderate attacks of pelvic inflammatory disease often respond to tetracycline, probably as a result of the drug's action on anaerobic bacteria and chlamydia.
Tetracyclines no longer can be entirely relied on in the treatment of streptococcal infections; up to 40% of Streptococcus pyogenes and 10% of Streptococcus pneu-moniae are resistant.
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