ability of (-blockers to reduce resting heart rate and increase diastolic perfusion time. Because subendocardial blood flow and flow distal to severe coronary artery stenosis occur primarily during diastole, this increase in diastolic perfusion time, due to the bradycardiac effect of propranolol and other (-blockers, would be expected to increase subendocardial blood flow to ischemic regions. (-Blockers have no significant effect on coronary collateral blood flow. Finally, there is evidence that (blockers can inhibit platelet aggregation.
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