Info

0/—

Coronary vascular resistance

Blood flow

+++

+++

++

Key: + = increase; — = decrease;0 = no significant effect.

*Changes are those seen commonly following oral doses used in therapy of hypertension or angina. The magnitude of response is indicated by number of symbols.

ever, dose-dependent depression is seen only with verapamil and diltiazem and not with nifedipine, reflecting mainly differences in the kinetics of their interaction at calcium channels (see section on calcium antagonism). Characteristic cardiac effects include a variable slowing of the heart rate, strong depression of conduction at the A-V node, and inhibition of contractility, especially in the presence of preexisting heart failure.

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