Info

"Blood Tissues

E, enterohepatic cycling;H, not recommended for patients with hepatic impairment;R, dosage adjustment necessary for patients with renal impairment;SZ, sulfasalazine;SP, sulfapyridine;Me, mesalamine.

"Blood Tissues

E, enterohepatic cycling;H, not recommended for patients with hepatic impairment;R, dosage adjustment necessary for patients with renal impairment;SZ, sulfasalazine;SP, sulfapyridine;Me, mesalamine.

Sulfasalazine can precipitate attacks of porphyria and should not be used by individuals with bowel or urinary obstruction.

Sulfasalazine can inhibit the absorption of cardiac glycosides and folic acid. It may displace certain drugs, including warfarin, phenytoin, methotrexate, tolbu-tamide, chlorpropamide, and oral sulfonylureas, from their protein binding sites. Sulfasalazine can diminish the effectiveness of penicillins and estrogen-containing oral contraceptives.

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