Info

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Chlorpromazine

Phenothiazine (Aliphatic)

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Thioridazine

Phenothiazine (Piperidine)

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"dj-Antiadrenergic and anticholinergic effects.

'Excluding tardive dyskinesia, which appears to be produced to the same degree and frequency by all agents except clozapine. cPimozide is used principally in the treatment of Tourette's syndrome.

"dj-Antiadrenergic and anticholinergic effects.

'Excluding tardive dyskinesia, which appears to be produced to the same degree and frequency by all agents except clozapine. cPimozide is used principally in the treatment of Tourette's syndrome.

thioridazine block a-adrenoceptors (autonomic side effects) more potently than D2-receptors and also block 5-HT2 serotonergic and Hj histamine receptors (sedative side effects) to a significant extent. However, their affinity for Dj-receptors is weak. Haloperidol and pimozide (Orap) act mainly on D2-receptors (extrapyramidal toxicity) with negligible activity at Dj-receptors. Clozapine, risperidone, and olanzapine (Zyprex) show marked clinical differences from the other drugs. Clozapine binds more to D4,5-HT2, aj-, and Hj-receptors (autonomic and sedative side effects) than to either D2 (low extrapyramidal activity) or Dj sites. Risperidone binds primarily to D2-, 5-HT2-, and aj-receptors, retaining high potency with lesser potential for side effects. Current drug development is directed toward a search for atypical antipsychotics like clozap-ine that have a broad spectrum of effects on other neu-rotransmitter receptors.

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