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Protozoal and helminthic infections are a major cause of disease in many parts of the world. Although some of these diseases are endemic to the United States or can be found in migrant workers or individuals returning from an endemic area, many other such infections are rarely seen in the United States. However, physicians should be aware of these diseases and seek advice from those experienced in their diagnosis and treatment.

Although the mode of action of many antiproto-zoals is not well understood, Table 53.1 summarizes the assumed or known modes of action of a number of the agents. The treatment of malaria is discussed at the end of this chapter.

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