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Muscarinic blocking drugs are compounds that selectively antagonize the responses to acetylcholine (ACh) and other parasympathomimetics that are mediated by activation of muscarinic receptors.These agents are also referred to as muscarinic antagonists, antimus-carinic drugs, and anticholinergics. The belladonna alkaloids, such as atropine, are the oldest known muscarinic blocking compounds, and their medicinal use preceded the concept of neurochemical transmission.

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