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*Includes parent compounds and active metabolites.

*Includes parent compounds and active metabolites.

of a particular benzodiazepine to treat a sleep disturbance is again generally based on pharmacokinetic criteria. While longer-acting compounds may ensure that a patient will sleep through the night, they also may cause cumulative effects resulting in daytime sluggishness or drug hangover. Shorter-acting compounds avoid the hangover problem, but their use may be associated with early awakening and an increase in daytime anxiety.

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