Endometrial cancer

^ Study Questions

1. Raloxifene is a SERM. A characteristic of SERMs is that they

(A) Act as estrogen agonists at all ERs

(B) Antagonize estrogens at all ERs

(C) Act as agonists at some and antagonists at other ERs

2. The most widely used type of oral contraceptive in the United States is

(A) Estrogen only

(B) Progestin only

(C) Combination of estrogen and progestin

3. Osteoporosis is the most serious effect of menopause. All of the following statements about osteoporosis are true EXCEPT

(A) Estrogen is an effective treatment.

(B) If endometrial cancer is a concern, a combination of estrogen and progestin should be considered.

(C) Vitamin D and calcium supplementation are alternatives to steroid hormone therapy.

(D) Bisphosphonates are ineffective in prevention of osteoporosis.

(E) Calcitonin is a useful alternative agent.

4. Breast cancer is the second most common cancer in women. All of the following statements concerning breast cancer at true EXCEPT

(A) Hormonal therapy is reserved for patients with advanced metastases.

(B) Estrogen treatment is an acceptable form of hormonal therapy.

(C) Progestin treatment is an accepted form of hormonal therapy.

(D) Tamoxifen is an accepted form of nonhormonal therapy.

5. The mechanism of action of the compound RU486 is to

(A) Block estrogen binding to ERs

(B) Block progestin binding to progesterone receptors

(C) Act as an estrogen agonist

(D) Act as a progesterone agonist

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