Info

of Selected Systems

of Trimethoprim

System

Age Adult Level Attained

Age t1/2 (hr)

Gastric acid production 3 mo

Gastric emptying 6-8 mo Hepatic metabolism

Phase I enzyme reactions 5 mo-5 yr

Phase II enzyme reactions 3-6 mo Excretion

Glomerular filtration 3-5 mo

Tubular secretion 6-9 mo

Renal blood flow 5-12 mo

Newborn 1-3 yr 8-10 yr Young adult

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