Info

F—; FPM;H?;R

"Average values for fasting adult patients following a single oral dose. 'Unchanged drug.

cData are given for non-delayed release formulations only. "After multiple dosing.

ADH, alcohol dehydrogenase;F+, food (high-fat meal) increases absorption;F—, food interferes with absorption;FPM, extensive first pass metabolism;GT, glucuronyl transferase;H?, dosage adjustment in patients with hepatic impairment has not been studied;ND, not deter-mined;R, dosage adjustment is necessary in patients with renal impairment.

"Average values for fasting adult patients following a single oral dose. 'Unchanged drug.

cData are given for non-delayed release formulations only. "After multiple dosing.

ADH, alcohol dehydrogenase;F+, food (high-fat meal) increases absorption;F—, food interferes with absorption;FPM, extensive first pass metabolism;GT, glucuronyl transferase;H?, dosage adjustment in patients with hepatic impairment has not been studied;ND, not deter-mined;R, dosage adjustment is necessary in patients with renal impairment.

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