Info

Young

Elderly

Drug

(20-30 yr)

(65-80 yr)

Penicillin G

20.7 min

39.1 min

Dihydrostreptomycin

5.2 hr

8.4 hr

Tetracycline

3.5 hr

4.5 hr

Kanamycin

107.0 min

282.0 min

Digoxin

52.0 hr

73.0 hr

Aminopyrine

3.0 hr

10.0 hr

Phenobarbital

71.0 hr

107.0 hr

Diazepam

20.0 hr

80.0 hr

Lidocaine

80.6 min

139.6 min

Chlordiazepoxide

8.9 hr

16.7 hr

Antipyrine

12.0 hr

17.4 hr

Phenylbutazone

81.2 hr

104.6 hr

Isoniazid

1.4 hr

1.5 hr

Warfarin

37.0 hr

44.0 hr

Source: Compiled from J.G. Ouslander, Drug therapy in the elderly. Ann. Intern. Med. 95:711,1981;and D.P. Richey and A.D. Bender, Pharmacokinetic consequences of aging. Annu. Rev. Pharmacol. Toxicol. 17:49,1977, and references therein.

Source: Compiled from J.G. Ouslander, Drug therapy in the elderly. Ann. Intern. Med. 95:711,1981;and D.P. Richey and A.D. Bender, Pharmacokinetic consequences of aging. Annu. Rev. Pharmacol. Toxicol. 17:49,1977, and references therein.

synthesis.These changes in serum albumin may affect the free drug concentration for a number of highly bound drugs, such as phenytoin, warfarin, and meperidine.

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