Info

2.30 brain (white) 1.70 brain (gray) 1.30 muscle

Adapted from Eger EI II (ed.). Anesthetic Uptake and Action. Baltimore: Williams & Wilkins, 1974:82.

Adapted from Eger EI II (ed.). Anesthetic Uptake and Action. Baltimore: Williams & Wilkins, 1974:82.

occur in these conditions. Also, tissues normally receiving a smaller proportion of the total cardiac output receive a greater amount when cardiac output is high and will accumulate a larger proportion of the anesthetic crossing the alveolar membrane. Ultimately, greater uptake will slow the rate of rise of the alveolar tensiontime curve, and anesthetic induction with an individual agent may be slower when the cardiac output and perfusion of the lung are high. In low cardiac output states, the reverse is true. The rate of uptake will be lower, and the alveolar tension will rise toward the inspired tension more quickly. To minimize the effect of cardiac output on the rate of induction of anesthesia, agents of lower solubility would be preferred clinically.

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