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Polybrominated and polychlorinated

biphenyls biphenyls genic, but rather they must be bioactivated to metabolites that are sufficiently reactive to bind to DNA and disrupt its coding. The reactive intermediates must be formed close enough to the DNA to interact with it before interacting with other less important macromole-cules or before being further metabolized to inactive forms. Nongenotoxic carcinogens act by altering cell replication control.

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