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aSpontaneous phase 4 depolarization. b Increase in the QTc interval.

SA, sinoatrial; D, decrease in conduction velocity; I, increase in conduction velocity; -, no significant effect with clinically relevant doses; ±, minimal effect.

aSpontaneous phase 4 depolarization. b Increase in the QTc interval.

SA, sinoatrial; D, decrease in conduction velocity; I, increase in conduction velocity; -, no significant effect with clinically relevant doses; ±, minimal effect.

that make up the class II drugs. Bear in mind the complete spectrum of cardiovascular effects of these agents when prescribing their use. For example, while patients with a normally functioning cardiovascular system may tolerate adrenergic blockade of the heart, patients with compensated heart failure, who depend on adrenergic tone to maintain an adequate cardiac output, may undergo acute congestive heart failure if prescribed any of the class II drugs. Table 16.5 summarizes the clinical use of the ß-adrenoceptor blocking drugs in the treatment of cardiac arrhythmias.

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