Immune globulin is isolated from pooled human plasma either from donors in the general population or from hyperimmunized donors. It is used principally in the treatment of certain immune deficiencies. Standard immune globulin solutions contain a distribution of all subclasses, with antibody titers for most major bacterial, viral, and fungal pathogens.
Immune globulin, given intramuscularly or intravenously, is recommended in the treatment of primary humoral immunodeficiency, congenital agammaglobu-linemias, common variable immunodeficiency, severe combined immunodeficiency, idiopathic thrombocy-topenic purpura, and autoimmune hemolytic anemia. There are six licensed preparations of immune globulin.
The principal side effects are possible anaphylactoid reactions and severe hypotension.
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