Propranolol decreases Purkinje fiber membrane responsiveness and reduces action potential amplitude. His-Purkinje tissue excitability also is reduced. These changes result in a decrease in His-Purkinje conduction velocity. However, these electrophysiological alterations are observed at propranolol concentrations in excess of those normally used in therapy. The most striking electrophysiological property of propranolol at usual therapeutic concentrations is a depression of catecholamine-stimulated automaticity.
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