Hemostatic Mechanisms

Endothelial cells maintain a nonthrombogenic lining in blood vessels. This results from several phenomena, including (1) the maintenance of a transmural negative electrical charge, which is important in preventing adhesion of circulating platelets; (2) the release of plasminogen activators, which activate the fibrinolytic pathway; (3) the activation of protein C, which degrades s

Contact activation

Exposure of blood to subendothelial vascular wall matrix

Vasoconstriction

Retarded blood flow

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