A unique property of bretylium as an antiarrhythmic agent is its positive inotropic action. This effect, related to its actions on the sympathetic nervous system, includes an initial release of neuronal stores of norepi-nephrine followed shortly by a prolonged period of inhibition of direct or reflex-associated neuronal nor-epinephrine release. The onset of bretylium-induced hypotension is delayed 1 to 2 hours because the initial cat-echolamine release maintains arterial pressure before this time.
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Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.