Glandular Tissue

Histamine stimulates the secretion of gastric acid and pepsin through an effect on the H2-receptors of the parietal cells of the gastric mucosa. Secretion of acid is a complex process that is stimulated by histamine, acetyl-choline, and gastrin and inhibited by somatostatin. The ability of H2-receptor antagonists to inhibit the enhanced gastric acid secretion caused by acetylcholine and gastrin suggests that histamine release is of primary importance in this process. Histamine also stimulates secretion by the salivary glands and glands in the small and large intestines. High concentrations of histamine promote the release of catecholamines from the adrenal gland.

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