Foscarnet (Foscavir) is an inorganic pyrophosphate analogue that acts in vitro against HSV-1,HSV-2,VZV, CMV, EBV, HBV, and HIV. It acts as a noncompetitive inhibitor of viral DNA polymerase and reverse transcriptase by re-versibly binding to the pyrophosphate-binding site of the viral enzyme and preventing the cleavage of pyrophosphate from deoxynucleoside triphosphates.

Resistance to foscarnet may result from mutation of viral DNA polymerase. Because this drug does not require phosphorylation for activation, thymidine kinase-deficient mutants should not be resistant to fos-carnet.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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